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Association between carotid artery intima-media thickness and early stage chronic kidney disease in a Chinese population
LuXia Zhang1, Feng Zhao2, Ying Yang2, LiTong Qi2, BaoWei Zhang2, Fang Wang1, ShuYu Wang3, LiSheng Liu3, HaiYan Wang1
1Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China
2 Division of Cardiology, Peking University First Hospital, Beijing, China
3 Hypertension League Institute, Beijing, China

Introduction.
Elevated carotid artery intima-media thickness (IMT) predicts future vascular events in the general population. Meanwhile the relationship between IMT and chronic kidney disease (CKD) has never been tested in subjects with mildly decreased renal function.

Methodology.
Carotid artery IMT was measured by high-resolution B-mode ultrasonography in 1046 residents in one district of Beijing. The estimated glomerular filtration rate (eGFR) was calculated using the modified Modification of Diet in Renal Disease (MDRD) equation based on data for Chinese CKD patients.

Results.
Compared with subjects with an eGFR>90ml/min/1.73m2, subjects with eGFR 60-89 ml/min/1.73m2 and 30-59 ml/min/1.73m2 had higher mean IMT (0.74ｱ0.27mm vs. 0.82ｱ0.30mm vs. 0.94ｱ0.38mm, P<0.001). Subjects with albuminuria tended to have higher levels of mean IMT (0.79ｱ0.29mm vs. 0.93ｱ0.38mm, P<0.001). Both eGFR and albuminuria correlated with mean IMT univariably. After adjusting for traditional risk factors, neither eGFR nor albuminuria independently associated with mean IMT.

Conclusion.
In this Chinese population older than 40 years, carotid artery IMT was significantly increased in subjects with mildly decreased eGFR. Factors associated with IMT were mainly the traditional risk factors of atherosclerosis.

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