5-4
Different Interrelationship of Metabolic Syndrome (MS) and Chronic Kidney
Disease (CKD) between Men and Women in Korea : Results from Korean National
Health and Nutrition Examination Survey (Korean NHANES)
M. A. Yu*1, J. H. Ryu1, D. R. Ryu1, S. J. Kim1, K. B. Choi1, K. I. Yoon1,
D. H. Kang1
1Nephrology, Ewha Womans University College of Medicine, Seoul, South
Korea
Introduction:
To understand the interrelationship between MS and CKD, we performed a
cross-sectional study in non-institutionalized Korean civilian using the
data of Korean NHANES in 2001. The Korean NHANES is a health survey of
a nationally representative sample of the Korean population.
Methods:
Of 7,918 participants, 5,715 at aged between 20 and 79 years were available
for analysis for the prevalence of CKD (defined as dipstick proteinuria
or a reduced GFR of < 60 ml/min per 1.73m2 by MDRD formula). MS was
diagnosed by NCEP-ATP III with the Asia-Pacific abdominal obesity criteria
(90 cm for men, 80 cm for women).
Results:
The prevalence of CKD was in 8.7% of subjects (7.2% in men and 9.9% in
women) and MS was seen in 25.7% (24.4% in men and 26.8% in women). The
prevalence of CKD increased with age, especially in individuals > 60
years of age and in both genders. Although MS was a significant determinant
of CKD in the entire subject group, [OR=1.68 (95% CI 1.36-2.09), p=.000],
subanalysis revealed that it was only significant in younger men (<60
years) [OR=2.49 (1.50 to 4.12, p=.000) in men<60, OR=1.04 (0.59 to
1.82, p=0.89) in menｳ60, OR=1.09 (0.69 to 1.72, p=0.73) in women<60,
OR=1.44 (0.95 to 2.17, p=.08) in womenｳ60]. Among five risk factors of
MS, all five components affected CKD in men<60 years [impaired fasting
glucose: OR=3.08 (1.94 to 4.89, p=0.000), high TG: OR=2.69 (1.71 to 4.25,
p=0.000), prehypertension: OR=2.65 (1.70 to 4.11, p=0.000), central obesity:
OR=2.41 (1.54 to 3.77, p=0.000), low HDL: OR=1.67 (1.08 to 2.58, p=0.02)]
whereas only central obesity, prehypertension and high TG related to CKD
in women<60 years [central obesity: OR=1.60 (1.13 to 2.27, p=0.008),
prehypertension: OR=1.80 (1.22 to2.66, p=0.003), high TG: OR=1.50 (1.02
to 2.20, p=0.04)].
Conclusion :
MS was a significant determinant of CKD in younger men (<60 years),
but not in the elderly population. In men, all five risk factors of MS
were related to CKD, but in women, only central obesity, prehypertension
and high TG were significant risk factors for CKD. In the elderly population,
not MS but aging and other risk factors may play a more important part
in the development of CKD.
